William Crumb: search on Z-Library

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1

Effects of Antipsychotic Drugs onIto,INa,Isus,IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

William J. Crumb, Sean Ekins, R. Dustan Sarazan, James H. Wikel, Steven A. Wrighton, Christopher Carlson, Charles M. Beasley

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 617 KB

english, 2006

2

American Orchestral; Commedia, for (Almost) 18th-Century Orchestra; Four Nocturnes (Night Music II) for Violin and Piano; Concerto for Violin and Orchestra; Untitled Compositions for Orchestra Nos.1 and 2; Amaryllis, Variants for Strings; Symphony No.10 'American Muse';

Dickinson, Peter, Bolcom, William, Crumb, George, Rochberg, George, Schafer, R. Murray, Schuman, William

Journal:

The Musical Times

Year:

1979

Language:

english

File:

PDF, 413 KB

english, 1979

3

ICH S7B draft guideline on the non-clinical strategy for testing delayed cardiac repolarisation risk of drugs: a critical analysis

Cavero, Icilio, Crumb, William

Journal:

Expert Opinion on Drug Safety

Year:

2005

Language:

english

File:

PDF, 231 KB

english, 2005

4

Rate-dependent blockade of a potassium current in human atrium by the antihistamine loratadine

William J Crumb Jr

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 254 KB

english, 1999

5

Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs

William Crumb, Amine Benyamina, Christophe Arbus, George P. Thomas, Ricardo P. Garay, Ahcène Hameg

Journal:

Journal of Pharmacy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 203 KB

english, 2008

6

Variability of the QTc interval: Impact on defining drug effect and low-frequency cardiac event

Joel Morganroth, Arthur M. Brown, Stuart Critz, William J. Crumb, Diana L. Kunze, Antonio E. Lacerda, Hector Lopez

Journal:

The American Journal of Cardiology

Year:

1993

Language:

english

File:

PDF, 575 KB

english, 1993

7

Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil

R. Dustan Sarazan, William J. Crumb Jr., Charles M. Beasley Jr., Jeffrey T. Emmick, Kenneth M. Ferguson, Christine A. Strnat, Peter J. Sausen

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 141 KB

english, 2004

8

Effects of cyamemazine on hERG, INa, ICa, Ito, Isus and IK1 channel currents, and on the QTc interval in guinea pigs

William Crumb, Pierre-Michel Llorca, Christophe Lancon, George P. Thomas, Ricardo P. Garay, Ahcène Hameg

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 271 KB

english, 2006

9

Stable expression and characterization of the human brain potassium channel Kv2.1: blockade by antipsychotic agents

Barbara Wible, Michael K Murawsky, William J Crumb Jr., David Rampe

Journal:

Year:

1997

Language:

english

File:

PDF, 352 KB

english, 1997

10

Prulifloxacin: in vitro (HERG current) and in vivo (conscious dog) assessment of cardiac risk

Pierre Lacroix, William J Crumb, Lucia Durando, Giovanni B Ciottoli

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 122 KB

english, 2003

11

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

William Crumb, Icilio Cavero

Journal:

Pharmaceutical Science & Technology Today

Year:

1999

Language:

english

File:

PDF, 293 KB

english, 1999

12

Can more be done with hERG data? The correlation of hERG block and QT prolongation

William J. Crumb Jr., Slavica Milosavljev, Sean Ekins

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 58 KB

english, 2012

13

Advantages and utility of native human cardiac myocytes in compound screening

William J. Crumb Jr., Slavica Milosavljev, Sean Ekins

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

14

L-type calcium current in pediatric and adult human atrial myocytes

Theresa P. Roca, John D. Pigott, Craig W. Clarkson, Arthur S. Pickoff, William J. Crumb Jr.

Journal:

Journal of the American College of Cardiology

Year:

1996

Language:

english

File:

PDF, 200 KB

english, 1996

15

[American Institute of Aeronautics and Astronautics 49th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference 16th AIAA/ASME/AHS Adaptive Structures Conference 10t - Schaumburg, IL ()] 49th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference <br> 16th AIAA/ASME/AHS Adaptive Structures Conference<br> 10t - Lightweight Deployable Sunshade Concepts for Passive Cooling of Space-Based Telescopes

Williams, R. Brett, Agnes, Gregory, Crumb, Dustin

Year:

2008

Language:

english

File:

PDF, 548 KB

english, 2008

16

Structure−Activity Relationships of 9-Substituted-9-Dihydroerythromycin-Based Motilin Agonists: Optimizing for Potency and Safety

Shaw, Simon J., Chen, Yue, Zheng, Hao, Fu, Hong, Burlingame, Mark A., Marquez, Saul, Li, Yong, Claypool, Mark, Carreras, Christopher W., Crumb, William, Hardy, Dwight J., Myles, David C., Liu, Yaoquan

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 901 KB

english, 2009

17

Integration of functional and biochemical biomarkers for verapamil-induced cardiac dysfunction

Roche, Brian, Crumb, William, Borders, Brandon, Ross, John, Wood, Brandon, Jalil, Amir, Henderson, Kim

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 57 KB

english, 2013

18

TEEN KNOWLEDGE OF LIFE-LONG CONGENITAL CARDIAC CARE

Fernandes, Susan M., Verstappen, Amy, Clair, Mathieu, Rummell, Mary, Mares, Joseph, Dummer, Kirsten, Barber, Deena, Crumb, Stephen, Bhatt, Ami, Cannobio, Mary, Takahashi, Masato, Williams, Roberta, La

Journal:

Journal of the American College of Cardiology

Year:

2013

Language:

english

File:

PDF, 145 KB

english, 2013

19

The use of electrocardiograms in clinical trials: a public discussion of the proposed ICH E14 regulatory guidance

Cavero, Icilio, Crumb, William

Journal:

Expert Opinion on Drug Safety

Year:

2005

Language:

english

File:

PDF, 91 KB

english, 2005

20

Electrocardiographic evidence for cocaine cardiotoxicity in cat

Crumb Jr., William J., Kadowitz, Philip J., Xu, You-Qiu, Clarkson, Craig W.

Journal:

Canadian Journal of Physiology and Pharmacology

Year:

1990

Language:

english

File:

PDF, 530 KB

english, 1990

21

Moving towards better predictors of drug-induced Torsade de Pointes

Cavero, Icilio, Crumb, William

Journal:

Expert Opinion on Drug Safety

Year:

2006

Language:

english

File:

PDF, 104 KB

english, 2006

22

Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

Cavero, Icilio, Mestre, Michel, Guillon, Jean-Michel, Crumb, William

Journal:

Expert Opinion on Pharmacotherapy

Year:

2000

Language:

english

File:

PDF, 603 KB

english, 2000

23

Safety Pharmacology Society: 5th Annual Meeting

Cavero, Icilio, Crumb, William

Journal:

Expert Opinion on Drug Safety

Year:

2006

Language:

english

File:

PDF, 92 KB

english, 2006

24

Oxytocin does not directly alter cardiac repolarization in rabbit or human cardiac myocytes

Qu, Yusheng, Fang, Mei, Gao, BaoXi, Amagasu, Shanti, Crumb, William J., Vargas, Hugo M.

Journal:

Pharmacology Research & Perspectives

Year:

2015

Language:

english

File:

PDF, 511 KB

english, 2015

25

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

Crumb, William J., Vicente, Jose, Johannesen, Lars, Strauss, David G.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 1.65 MB

english, 2016

26

Comprehensive Translational Assessment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias

Blinova, Ksenia, Stohlman, Jayna, Vicente, Jose, Chan, Dulciana, Johannesen, Lars, Hortigon-Vinagre, Maria P., Zamora, Victor, Smith, Godfrey, Crumb, William J., Pang, Li, Lyn-Cook, Beverly, Ross, Jam

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 2.23 MB

english, 2016

27

Detection of hERG-trafficking in vitro: A comparison of functional and protein expression methods

Qu, Yusheng, Crumb, William, Vargas, Hugo

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 51 KB

english, 2016

28

In vitro to clinical translation to improve proarrhythmic risk assessment

Strauss, David, Vicente, Jose, Mason, Jay, Crumb, William, Hosseini, Meisam, Stockbridge, Norman, Johannesen, Lars

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

29

Biophysical and pharmacological characterization of the CiPA ion channel panel and iPSC cardiomyocytes using automated patch-clamp

Scheel, Olaf, Frech, Stefanie, Amuzescu, Bogdan, Crumb, William, Roberts, Mike, Knott, Thomas

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 48 KB

english, 2016

30

Validation of a [3H]Astemizole Binding Assay in HEK293 Cells Expressing HERG K+ Channels

Chiu, Peter J.S., Marcoe, Karen F., Bounds, Sidney E., Lin, Chun-Hsiung, Feng, Jin-Jye, Lin, Atsui, Cheng, Fong-Chi, Crumb, William J., Mitchell, Richard

Journal:

Journal of Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 314 KB

english, 2004

31

Nonclinical Profile of BLZ-100, a Tumor-Targeting Fluorescent Imaging Agent

Parrish-Novak, Julia, Byrnes-Blake, Kelly, Lalayeva, Narine, Burleson, Stefanie, Fidel, Janean, Gilmore, Rhonda, Gayheart-Walsten, Pamela, Bricker, Gregory A., Crumb, William J., Tarlo, K. S., Hansen,

Journal:

International Journal of Toxicology

Year:

2017

Language:

english

File:

PDF, 386 KB

english, 2017

32

Impact of Disease State on Arrhythmic Event Detection Using APD Modeling

Crumb, William, Christophe, Bernard, Shah, Rashmi

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 51 KB

english, 2017

33

Evaluation of Patch Clamp at Physiological Temperature on Isolated iPSC Cardiomyocytes As a Tool to Compare Different iPSC Cardiomyocytes Including Patient Specific iPSC Cardiomyocytes

Knott, Thomas, Zhang, Jie, Crumb, William

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 48 KB

english, 2017

34

Impact of disease state on arrhythmic event detection by action potential modelling in cardiac safety pharmacology

Christophe, Bernard, Crumb, William J.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 756 KB

english, 2018

35

A risk profile of fenspiride using ion channel data and in silico action potential modeling

Crumb, William, Christophe, Bernard

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2020

File:

PDF, 60 KB

2020

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